About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
Speaker: Dr. María Alieva, research group at the Sols-Morreale Biomedical Research Institute (CSIC-UAM)
By offering spatial, molecular, and morphological data over time, live-cell imaging provides a deeper comprehension of cellular and signaling events pivotal in cancer-related processes, such as tumor heterogeneity, treatment response, and tumor invasion. This dynamic cellular response holds promise in refining clinical outcomes by pinpointing biomarkers or actionable targets to enhance therapeutic effectiveness. Nevertheless, live imaging of intricate systems, like co-culture assays or intravital microscopy and organotypic brain slices, generates big and complex datasets, necessitating tailored analytical pipelines to interpret the vast amount of dynamic features captured. Dr. Alieva's group, imAIgene lab, specializes in computational approaches for dynamic imaging analysis. Their focus lies in gaining insights into various aspects of cancer biology, including cellular immunotherapy mode-of-action against tumors, tumor heterogeneity in treatment response, and tumor invasion. In this seminar, Dr. Alieva will highlight several recent research applications that offer biological insights into these topics. These applications encompass a range of techniques, from single-cell dynamic classification and dynamic cellular interactome analysis to the utilization of organoid models for studying intratumor heterogeneity. Additionally, the lab employs multi-omics approaches that integrate imaging with single-cell transcriptomic information, to leverage the results from dynamic imaging assays to improve therapeutic efficacy and facilitate biomarker discovery.
Host: Dr. Juan Ángel Recio, Head of group Biomedical Research in Melanoma (VHIR)